6-Bromohexanoic acid (Health & Beauty - Other Health Ads)

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6-Bromohexanoic acid


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CAS: 4224-70-8
MF: C6H11BrO2
MW: 195.05
EINECS: 224-176-5
Product Categories: C6;Carbonyl Compounds;omega-Functional Alkanols, Carboxylic Acids, Amines & Halides;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks;Organic acids;Acids & Esters;Bromine Compounds;omega-Bromocarboxylic Acids;Aliphatics;Miscellaneous Reagents;Building Blocks
Mol File: 4224-70-8.mol
Article illustration

6-Bromohexanoic acid Chemical Properties
Melting point 32-34 °C (lit.)
Boiling point 165-170 °C/20 mmHg (lit.)
density 1.3996 (rough estimate)
refractive index 1.4790 (estimate)
Fp 154 °F
storage temp. Inert atmosphere,2-8°C
solubility methanol: 0.1 g/mL, clear, colorless
pka 4.72±0.10(Predicted)
form Low Melting Crystals
color White to light orange
BRN 1749740
InChIKey NVRVNSHHLPQGCU-UHFFFAOYSA-N
LogP 1.700 (est)
CAS DataBase Reference 4224-70-8(CAS DataBase Reference)
NIST Chemistry Reference Hexanoic acid, 6-bromo-(4224-70-8)
EPA Substance Registry System Hexanoic acid, 6-bromo- (4224-70-8)
6-Bromohexanoic acid Usage And Synthesis
Organic Intermediate 6-bromohexanoic acid(CAS:4224-70-8), also called 6-bromohexanoic acid or 6-bromo-hexanoic acid, is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. 6-Bromohexanoic acid is used in the preparation of N-acylsulfonamides, diarylthioethers and 2-lithio-1,3-dithian. It is widely used as an intermediate in organic synthesis. Here, we introduced a method for making this compound.
Chemical Properties White to light orange low melting crystals
Uses Employed in a direct preparation of N-acylsulfonamides on treatment with tosyl isocyanate (189278)1 and alkyl ketones from alkyl iodides and metallic strontium.2
Uses 6-Bromohexanoic acid is used in the preparation of N-acylsulfonamides, diarylthioethers and 2-lithio-1,3-dithian. It is widely used as an intermediate in organic synthesis.
Uses 6-Bromohexanoic acid was used in the preparation of N-acylsulfonamides on treatment with tosyl isocyanate (189278) and alkyl ketones from alkyl iodides and metallic strontium. It was also used in the synthesis of anionic mitomycin C-dextran conjugate (MMC-D), 2-lithio-1,3-dithian and diaryl thioethers.
Definition ChEBI: 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It is functionally related to a hexanoic acid.
Synthesis Reference(s) Journal of the American Chemical Society, 72, p. 5137, 1950 DOI: 10.1021/ja01167a091
Synthesis The preparation method of the high purity 6-bromocaproic acid: the exsiccant bromize hydrogen gas is directly fed contain in the organic solvent of 6-caprolactone, exsiccant bromize hydrogen gas usage quantity is 6-caprolactone 1.0-2.0 doubly (mol ratio); Stir, ring-opening reaction takes place, temperature of reaction is 0 ℃ ~ 100 ℃, generates high purity 6-bromocaproic acid.
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Last Update : Apr 24, 2024 4:11 AM
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